Name: Olmesartan Loaded Solid Lipid Nanoparticles-Pharmacokinetics Studies (en Inglés)
Price: 398.10 PEN
Availability: InStock
Author: Okorie, Ndidiamaka Hannah ; Mbah, Chika John ; Attama, Anthony A.
ISBN: 9786139487356

portada Olmesartan Loaded Solid Lipid Nanoparticles-Pharmacokinetics Studies (en Inglés)

Formato

Libro Físico

Autor

Ndidiamaka Hannah Okorie

Chika John Mbah

Ilustrado por

Anthony A. Attama

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

160

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 0.9 cm

Peso

0.24 kg.

ISBN13

9786139487356

Categorías

Farmacología

Olmesartan Loaded Solid Lipid Nanoparticles-Pharmacokinetics Studies (en Inglés)

Ndidiamaka Hannah Okorie (Autor) · Chika John Mbah (Autor) · Anthony A. Attama (Ilustrado por) · LAP Lambert Academic Publishing · Tapa Blanda

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Origen: Estados Unidos (Costos de importación incluídos en el precio)

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Reseña del libro "Olmesartan Loaded Solid Lipid Nanoparticles-Pharmacokinetics Studies (en Inglés)"

Olmesartan medoxomil (OLM), is a diphenyl tetrazole analogue belonging to the class of angiotensin II receptor antagonists which is used clinically in treatment of hypertension. It is practically insoluble in water and has oral bioavailability of 26%. Solid lipid nanoparticles (SLN), have been developed for various routes of administration with several objectives including enhancement of bioavailability of poor water soluble drugs. OLM loaded SLN formulation was prepared by hot homogenization and ultra-sonication method. The SLN formulations were characterized and optimized..In-vitro drug release studies were performed using dialysis bag. The drug release kinetics of five optimized formulations were evaluated by fitting the data into various kinetics models. The characterization as well drug release studies data gave two optimized formulations (F3 and F7) which were used for pharmacokinetics studies. The formulations were found to enhance the bioavailability of OLM by 2.2 and 2.5 folds-increase respectively, compared to the aqueous solution of oral tablet.The work suggest that SLN formulation could be an effective oral drug delivery system to improve bioavailability of Olmesartan.