Name: Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications (en Inglés)
Price: 972.11 PEN
Availability: InStock
Author: March, Keith L.
ISBN: 9781461378815

portada Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications (en Inglés)

Formato

Libro Físico

Editorial

Springer

Autor

March, Keith L.

Idioma

Inglés

N° páginas

516

Encuadernación

Tapa Blanda

Dimensiones

23.4 x 15.6 x 2.8 cm

Peso

0.75 kg.

ISBN13

9781461378815

Categorías

Génetica médica
Enfermedades cardiovasculares
Mamíferos

Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications (en Inglés)

March, Keith L. (Autor) · Springer · Tapa Blanda

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Reseña del libro "Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications (en Inglés)"

The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled "Artificial Self-Assembling Systems for Gene Transfer", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: - size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . - potential tumorigenesis (e. g. retrovirus) - potential for insertional mutagenesis (greater than plasmid based systems) - potential imrnunogenicity (e. g.